In Europe, the landscape mosaic pattern is changing due to two opposing landscape processes that are driven by either anthropogenic or natural factors. Such changes have an impact on the supply of ecosystem functions and services such as habitat provision, species dispersal, pollination, pest control or climate mitigation. Anthropogenic driven fragmentation factors are mainly the expansion of agricultural areas, transport infrastructures, settlements and the occurrence of fires. Defragmentation processes occur mainly due to natural factors like the increase of woody vegetation, which follows land abandonment. Spatially explicit information on the pattern of natural/semi-natural lands is also relevant to help to build a green infrastructure for Europe, which aims, amongst others, to develop networks of green, natural features, address impacts of urban sprawl and fragmentation, increase connectivity and improve landscape permeability.